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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name CARM1 siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods Western blot, qRT-PCR, immunofluorescence, immunohistochemistry, siRNA transfection, Hoechst staining
Expression pattern associated
Functional description Silencing of CARM1 expression by siRNA and pharmacological inhibition of CARM1 activity abolished high-glucose-induced RPE cell apoptosis.
PubMed ID 25072916
Year 2014
Title High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: role in diabetic retinopathy.
Drug-related ncRNA NO

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